Simulation is a component of health care education and has provided active learning experiences in a clinical laboratory setting for students for countless years. Utilizing simulators is an evidence-based teaching approach that is widely accepted and incorporated in health care education programs including nursing, advanced practice nursing, respiratory therapy, and athletic training programs. In the simulation laboratory, students experience the "next best thing" to a live patient-care setting. A simulation activity can also provide students an opportunity to develop greater self-efficacy and a better understanding of the roles and responsibilities of other health care professions. Self-efficacy is defined as “being concerned with judgments of how well one can execute courses of action required to deal with prospective situations”. The Interprofessional Education Collaborative (IPEC, 2016) identified 4 core competencies for Interprofessional Collaborative Practice. They include Values/Ethics, Roles/Responsibilities, Interprofessional Communication, Teams, and Teamwork. For this project, we will use the Self-Efficacy for Interprofessional Experiential Learning (SEIEL, Mann et al., 2012) inventory to measure self-efficacy among health profession students before and after an interprofessional education (IPE) simulation exercise. We hypothesize that a simulation activity that includes multiple health care professional students will improve student self-efficacy of interprofessional interaction and interprofessional team evaluation and feedback. The health profession programs include Nursing (BSN and DNP), Respiratory Therapy, Athletic Training, and Exercise Science. These students participating in an IPE simulation event will directly focus on interprofessional learning for collaborative practice and education. Healthcare teams today center around the collaborative practice to improve patient outcomes through clinical practice and identifying opportunities for education. The healthcare system is constantly evolving, and the IPE of healthcare professions will need to maintain the pace to advocate for collaboration in the coordination of healthcare services.